Researchers identifies Molecule that 'Cures Malaria in Mice'
Cape Town — Researchers say they have identified a possible single-dose malaria cure molecule, with the potential to cure millions of people and, it is hoped, to prevent person-to-person transmission. The molecule, MMV390048, was discovered during collaborative research by the Drug Discovery and Development Centre (H3-D) at the University of Cape Town (UCT), South Africa, and Geneva-based Medicines for Malaria Venture (MMV). Tests indicate that the molecule is highly potent: after being administered a single dose, mice infected with malaria parasites were completely cured, and the molecule is also active against wide-ranging drug-resistant malaria strains. MMV390048 is due to enter the clinical trials stage late in 2013. Kelly Chibale, H3-D's director, said he was very excited that MMV390048 has been selected for further development. "Our team is hopeful that the compound will emerge from rigorous testing as an extremely effective medicine for malaria," he said....